Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence

  title={Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence},
  author={Piotr Piotrowski and Robert Gasik and Margarita Lianeri and Dorota Cieślak and Mariusz Wudarski and Paweł Hrycaj and Jan Łącki and Paweł Piotr Jagodziński},
  journal={Molecular Biology Reports},
Endogenous sex hormones have been observed to have a role in systemic lupus erythematosus (SLE) predisposition. Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex hormones to target tissues. Therefore, we examined the distribution of the SHBG functional polymorphism Asp327Asn (rs6259) in SLE patients (n = 150) and controls (n = 150) in a Polish population. We found a contribution of the SHBG327Asn variant to the development of SLE. Women with the Asp/Asn and Asn/Asn… 
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