Asociación entre los polimorfismos de los genes de la enzima convertidora de angiotensina y los receptores AT1R y AT2R y el cáncer de mama: Estudio de casos y controles

  title={Asociaci{\'o}n entre los polimorfismos de los genes de la enzima convertidora de angiotensina y los receptores AT1R y AT2R y el c{\'a}ncer de mama: Estudio de casos y controles},
  author={D Andr{\'e}sFelipeCastro and Nelsy Loango and Bayron Alexander Ruiz and Patricia Land{\'a}zuri},
Introduction: breast cancer is the second most common type of cancer and the fifth cause of death due to cancer around the world. The components of the renin-angiotensin system are potential candidates for chemoprevention therapy: the angiotensin converter enzyme (ACE) and type 1 and 2 angiotensin II receptors (AT1R and AT2R).Objective: establishing an association between ACE gene polymorphisms, AT1R and AT2R receptors and breast cancer.Materials and methods: 50 cases and 50 controls were… Expand
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Association of ACE I/D, -240A > T and AT1R A1166C polymorphisms with susceptibility to breast cancer: a systematic review and meta-analysis based on 35 case-control studies
This meta-analysis inconsistence with all previous meta-analyses suggests that the ACE I/D might be associated with BC in overall and by ethnicity. Expand


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The results suggest that AGT plays a role in breast cancer risk in postmenopausal women, whereas the role of AGTR1 needs further studying. Expand
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Results of this work supports previous observations on the possible involvement of this system in breast cancer but it also suggests a role in benign disease. Expand
Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Breast Cancer Risk
The results suggest that the ACE I/D polymorphism plays an important role in breast cancer risk and disease-free survival in Caucasian postmenopausal women. Expand
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
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The data do not support the hypothesis that women with lower ACE levels, as predicted by the low-activity A and I ACE alleles, are at reduced risk of breast cancer, and suggest that the A-240T and I/D ACE polymorphisms are not likely to be strong predictors of Breast cancer risk. Expand
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Examination of genetic polymorphisms in the 5'-region of the AGTR1 gene in relation to risk of breast cancer in 258 breast cancer cases and 670 female controls within the Singapore Chinese Health Study suggests that pharmacological inhibition of the angiotensin II effect by blockade of ACE and/or AG TR1 could be potential targets for the prevention and treatment of Breast cancer. Expand
Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore.
The findings support experimental data implicating ACE and angiotensin II in breast cancer, and suggest that the renin-angiotens in system may serve as a therapeutic target for breast cancer treatment and prevention. Expand
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