Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts

@article{Tang2010AsiaticosideSC,
  title={Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts},
  author={Bing Tao Tang and Bin Zhu and Yueying Liang and Liangkuan Bi and Zhicheng Hu and Bin Chen and Kai Zhang and Jiayuan Zhu},
  journal={Archives of Dermatological Research},
  year={2010},
  volume={303},
  pages={563-572}
}
Asiaticoside (ATS) isolated from the leaves of Centella asiatica possesses strong wound-healing properties and reduces scar formation. However, the specific effects of asiaticoside on the formation of keloidal scars remain unknown. In the present study, we evaluated the in vitro effects of asiaticoside on the proliferation, collagen expression, and transforming growth factor (TGF)-β/Smad signaling of keloid-derived fibroblasts. Fibroblasts isolated from keloid tissue and normal skin tissues… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

TGF-beta signaling and the fibrotic response.

  • Andrew Leask, David J. Abraham
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2004
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

possible involvement of the IKK and MAPK pathways

  • Yun K-J, Kim J-Y, +8 authors PGE2 production by asiatic acid via NF-kappa B inactiva macrophages
  • Int Immunopharmacol 8:431–441 572 Arch Dermatol Res
  • 2011
VIEW 1 EXCERPT

Genetics of keloid scarring

VIEW 1 EXCERPT

Hypertrophic scars and keloids--a review of their pathophysiology, risk factors, and therapeutic management.

VIEW 3 EXCERPTS

Keloid scarring: bench and bedside

VIEW 2 EXCERPTS