Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells.

  title={Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells.},
  author={Byung Chul Park and Kefa Ogonyo Bosire and Eung-Seok Lee and Yong Soo Lee and Jung-Ae Kim},
  journal={Cancer letters},
  volume={218 1},
Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study, the mechanism of anticancer effect of AA on skin cancer was investigated. AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a time- and dose-dependent manner. AA also markedly increased intracellular reactive oxygen species (ROS) level and enhanced the expression of Bax but not Bcl-2 protein in the cells. In addition, AA-induced activation of caspase-3 activity in a… CONTINUE READING
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