Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats

@inproceedings{Maneesai2016AsiaticAA,
  title={Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats},
  author={Putcharawipa Maneesai and Sarawoot Bunbupha and Veerapol Kukongviriyapan and Parichat Prachaney and Panot Tangsucharit and Poungrat Pakdeechote},
  booktitle={BMC complementary and alternative medicine},
  year={2016}
}
BACKGROUND In the rat model of high carbohydrate, high fat (HCHF) diet-induced metabolic syndrome (MS), previous studies have found that asiatic acid has an antihypertensive effect. In this study, we investigated effects of asiatic acid on vascular structure, vascular function and renin-angiotensin system (RAS) in HCHF diet-induced MS rats. METHODS Male Sprague-Dawley rats were divided into three treatment groups for the 15 week study: a control group fed a normal diet, a MS group fed HCHF… CONTINUE READING
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