Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

  title={Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of $\alpha$-Synuclein Into Mitochondria},
  author={Hongqun Ding and Yuyun Xiong and Jing Sun and Chen Chen and Jing Gao and Huaxi Xu},
  journal={Frontiers in Neuroscience},
The association of α-synuclein (α-syn) with mitochondria occurs through interaction with mitochondrial complex I. Defects in this protein have been linked to the pathogenesis of Parkinson disease (PD). Overexpression of α-synuclein in cells has been suggested to cause elevations in mitochondrial oxidant radicals and structural and functional abnormalities in mitochondria. Asiatic acid (AA), a triterpenoid, is an antioxidant that is used for depression, and we have shown that pretreatment with… 

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