Asian-american variants of human papillomavirus type 16 have extensive mutations in the E2 gene and are highly amplified in cervical carcinomas.

@article{Casas1999AsianamericanVO,
  title={Asian-american variants of human papillomavirus type 16 have extensive mutations in the E2 gene and are highly amplified in cervical carcinomas.},
  author={Leonora Casas and Silvia Carolina Galv{\'a}n and Rosa Ma Ord{\'o}{\~n}ez and Nelson Lopez and Maria Guido and Jaime Berumen},
  journal={International journal of cancer},
  year={1999},
  volume={83 4},
  pages={449-55}
}
Human-papillomavirus (HPV)-E2 protein is involved in gene-expression regulation and replication of HPV genome. Disruption of the E2 gene during viral integration has been proposed as a mechanism of tumoral progression, since the expression of E6/E7 viral oncogenes is allowed. However, retention of E1/E2 genes and high viral amplification are frequently found in HPV16-positive carcinomas of some populations. In this study, we investigated whether retention of E1/E2 and viral amplification are… CONTINUE READING