Asialoerythropoietin prevents contrast-induced nephropathy.

  title={Asialoerythropoietin prevents contrast-induced nephropathy.},
  author={Yukiyo Yokomaku and Toshiro Sugimoto and Shinji Kume and Shin-Ichi Araki and Keiji Isshiki and Masami Chin-Kanasaki and Masayoshi Sakaguchi and Norihisa Nitta and Masakazu Haneda and Daisuke Koya and Takashi Uzu and Atsunori Kashiwagi},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={19 2},
Strategies to prevent contrast-induced nephropathy (CIN) are suboptimal. Erythropoietin was recently found to be cytoprotective in a variety of nonhematopoietic cells, so it was hypothesized that the nonhematopoietic erythropoietin derivative asialoerythropoietin would prevent CIN. Nephropathy was induced in rats by injection of the radiocontrast medium Ioversol in addition to inhibition of prostaglandin and nitric oxide synthesis. Administration of a single dose of asialoerythropoietin before… CONTINUE READING
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