AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2.

@article{McNamara2006AsialoGM1AT,
  title={AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2.},
  author={Nancy A McNamara and Marianne Gallup and Anatol Sucher and Inna Maltseva and D D Mckemy and Carol Basbaum},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={34 6},
  pages={653-60}
}
Bacterial flagellin can interact with both Toll-like receptor 5 (TLR5) and the cell surface glycolipid, asialoGM1, to activate an innate immune response. The induction of mucin by flagellin in human lung epithelial cells (NCIH292) is dependent on asialoGM1 ligation, ATP receptor signaling, Ca2+ mobilization, and Erk1/2 activation. Conversely, the activation of NF-kappaB by flagellin is dependent on signaling through TLR5. These results prompted us to ask whether the flagellin-induced TLR5… CONTINUE READING
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