Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.

@article{Schwabish2006Asf1MH,
  title={Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.},
  author={Marc A. Schwabish and Kevin Struhl},
  journal={Molecular cell},
  year={2006},
  volume={22 3},
  pages={415-22}
}
Histones are rapidly evicted and deposited during transcription by RNA polymerase (Pol) II, but a factor that mediates histone eviction in vivo has not yet been identified. Here, we show that the histone chaperone Asf1 associates with promoters and coding regions of transcriptionally active genes. Asf1 mediates histone H3, but not H2B, eviction and deposition during Pol II elongation, suggesting that nucleosome assembly and disassembly occur in a stepwise fashion. Lastly, Asf1 inhibits internal… CONTINUE READING

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