Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells.

@article{Sanematsu2006Asf1IR,
  title={Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells.},
  author={Fumiyuki Sanematsu and Yasunari Takami and Hirak Kumar Barman and Tatsuo Fukagawa and Tatsuya Ono and Kei-ichi Shibahara and Tatsuo Nakayama},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 19},
  pages={13817-27}
}
Asf1 (anti-silencing function 1), a well conserved protein from yeast to humans, acts as a histone chaperone and is predicted to participate in a variety of chromatin-mediated cellular processes. To investigate the physiological role of vertebrate Asf1 in vivo, we generated a conditional Asf1-deficient mutant from chicken DT40 cells. Induction of Asf1 depletion resulted in the accumulation of cells in S phase with decreased DNA replication and increased mitotic aberrancy forming multipolar… CONTINUE READING

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