Asenapine: a novel psychopharmacologic agent with a unique human receptor signature

@article{Shahid2009AsenapineAN,
  title={Asenapine: a novel psychopharmacologic agent with a unique human receptor signature},
  author={M. Shahid and G. Walker and S. Zorn and E. Wong},
  journal={Journal of Psychopharmacology},
  year={2009},
  volume={23},
  pages={65 - 73}
}
Asenapine is a novel psychopharmacologic agent under development for the treatment of schizophrenia and bipolar disorder. We determined and compared the human receptor binding affinities and functional characteristics of asenapine and several antipsychotic drugs. Compounds were tested under comparable assay conditions using cloned human receptors. In comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pK i) for serotonin receptors… Expand
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