Asenapine, Blonanserin, Iloperidone, Lurasidone, and Sertindole: Distinctive Clinical Characteristics of 5 Novel Atypical Antipsychotics

@article{Wang2013AsenapineBI,
  title={Asenapine, Blonanserin, Iloperidone, Lurasidone, and Sertindole: Distinctive Clinical Characteristics of 5 Novel Atypical Antipsychotics},
  author={Sheng-Min Wang and Changsu Han and Soo-Jung Lee and Ashwin A. Patkar and Prakash S. Masand and Chi-Un Pae},
  journal={Clinical Neuropharmacology},
  year={2013},
  volume={36},
  pages={223–238}
}
AbstractSchizophrenia is a serious, chronic, and devastating mental illness with a substantial impact on psychological, physical, social, and economical areas of an individual and society. To treat such critical mental illness, a number of first-generation (typical) and second-generation (atypical) antipsychotics are currently available in the market. Despite such treatment options, most of patients with schizophrenia have a poor treatment outcome and become treatment resistant, causing… 

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References

SHOWING 1-10 OF 102 REFERENCES

Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults

  • W. Bobo
  • Medicine, Psychology
    Expert review of clinical pharmacology
  • 2013
TLDR
For each drug, comparative and real-world effectiveness studies are lacking, as are effectiveness and safety data in elderly, young and pregnant/nursing patients, and the exact place of iloperidone, asenapine and lurasidone within the broader antipsychotic armamentarium is currently difficult to establish.

The Efficacy and Safety of Blonanserin Compared with Haloperidol in Acute-Phase Schizophrenia

TLDR
Boonserin was effective in the treatment of acute schizophrenia and showed greater efficacy in negative symptoms compared with placebo and haloperidol, and blonanserin (5 and 10 mg) was more effective against the negative symptoms than haloperIDol.

Asenapine: a clinical overview.

  • S. Potkin
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 2011
TLDR
Asenapine is a new, second-generation antipsychotic medication with demonstrated efficacy for the acute and maintenance treatment of schizophrenia and may be a helpful treatment option for patients with schizophrenia when weight gain, dyslipidemia, and endocrine abnormalities are a concern.

Iloperidone: A new drug for the treatment of schizophrenia.

  • Sally A. ArifMelissa Mitchell
  • Medicine, Psychology
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2011
TLDR
Iloperidone may be a viable and safe option for the treatment of schizophrenia in adult patients, especially for patients who cannot tolerate other antipsychotic agents.

Asenapine: a clinical review of a second-generation antipsychotic.

Blonanserin: a review of its use in the management of schizophrenia.

TLDR
Clinical data suggest that blonanserin is an effective and generally well tolerated option for the short-term treatment of schizophrenia and for those requiring longer-term therapy.

Iloperidone for the management of adults with schizophrenia.

Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial.

TLDR
Asenapine was effective and well tolerated in patients with acute schizophrenia and may provide a new option for control of negative symptoms.

Clinical potential of lurasidone in the management of schizophrenia

TLDR
Lurasidone differs from the other second-generation antipsychotics by having a good tolerability profile, in particular for cardiometabolic tolerability, but seems to have a significant although moderate link with the occurrence of akathisia, extrapyramidal symptoms, and hyperprolactinemia at the start of treatment.

Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial.

TLDR
The results of this study suggest that the novel psychotropic agent lurasidone is a safe and effective treatment for patients with an acute exacerbation of schizophrenia.
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