Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae
@article{Suga2015AscosterosideCA, title={Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae}, author={Takuya Suga and Yukihiro Asami and Shohei Hashimoto and Ken'ichi Nonaka and Masato Iwatsuki and Takuji Nakashima and Ryohei Sugahara and Takahiro Shiotsuki and Takenori Yamamoto and Yasuo Shinohara and Naoya Ichimaru and Masatoshi Murai and Hideto Miyoshi and Satoshi Ōmura and Kazuro Shiomi}, journal={The Journal of Antibiotics}, year={2015}, volume={68}, pages={649-652} }
Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae
7 Citations
Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae
- BiologyThe Journal of Antibiotics
- 2018
A new lanostane-type triterpenoid was isolated from a fungus, Aspergillus sp.
Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae
- Biology, ChemistryThe Journal of Antibiotics
- 2017
A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817 and elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes.
Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system.
- BiologyThe Journal of general and applied microbiology
- 2015
In the course of searching for insecticides from soil microorganisms, we found that a fermentation broth of the fungus, Trichoderma brevicompactum FKI-6324, produced Trichopolyn VI, a new peptaibol,…
Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria
- Biology, ChemistryJournal of industrial microbiology & biotechnology
- 2021
Two new tetramic acid derivatives, traminines A and B, isolated from a culture broth of Fusarium concentricum FKI-7550 by bioassay-guided fractionation strongly suggest that they target mitochondrial machineries presiding over ATP production via oxidative phosphorylation.
Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus
- BiologyThe Journal of Antibiotics
- 2018
A new antibiotic, named pestiocandin (1), is isolated from a culture broth of a filamentous fungus, Pestalotiopsis humus FKI-7473, using a multidrug-sensitive budding yeast, S. cerevisiae 12geneΔ0HSR-iERG6, and displayed more potent growth inhibition against multidrog-sensitive yeasts than wild-type yeasts.
Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae
- Biology, ChemistryThe Journal of Antibiotics
- 2019
A new compound, fusaramin, along with three known compounds, was isolated from a culture broth of Fusarium sp.
Triterpenoids.
- ChemistryNatural product reports
- 2020
This review covers the isolation and structure determination of triterpenoids reported during 2015 including squalene derivatives, lanostane derivatives, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins.
References
SHOWING 1-10 OF 21 REFERENCES
Ascosteroside, a new antifungal agent from Ascotricha amphitricha. II. Isolation and structure elucidation.
- Chemistry, BiologyThe Journal of antibiotics
- 1996
The novel antifungal agent ascosteroside (1) was isolated from cultured broth of Ascotricha amphitricha (ATCC 74237). The structure based on spectroscopic data was determined to be an alpha-linked…
On the mode of action of a new antifungal antibiotic, aculeacin A: inhibition of cell wall synthesis in Saccharomyces cerevisiae.
- Biology, EngineeringThe Journal of antibiotics
- 1977
The mode of action of a new antifungal antibiotic, aculeacin A, was studied with the cells of Saccharomyces cerevisiae, and the distinct decrease of viable cells was observed.
Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis.
- ChemistryJournal of natural products
- 2003
Compound 1 showed weak inhibitory activity against the growth of various tumor cells and inhibited HIV-1 protease and the absolute configuration of 1 was determined.
Cyflumetofen, a novel acaricide - its mode of action and selectivity.
- Biology, MedicinePest management science
- 2013
The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1, which was detected as the main metabolite in mites.
Inhibition of electron transfer from ferrocytochrome b to ubiquinone, cytochrome c1 and duroquinone by antimycin.
- Biology, ChemistryBiochimica et biophysica acta
- 1975
First detection of chlorfenapyr (Secure®) resistance in two-spotted spider mite (Acari: Tetranychidae) from nectarines in an Australian orchard
- BiologyExperimental & Applied Acarology
- 2004
Chlorfenapyr resistance was detected in Tetranychus urticae Koch causing control failure following a single application of product to nectarines.
Interaction of (3H) bongkrekic acid with the mitochondrial adenine nucleotide translocator.
- Biology, ChemistryBiochemistry
- 1976
The transition from a mixed-type inhibition, with high Ki value, to an uncompetitive type of inhibition, which suggests the formation of a ternary complex, carrier-ADP-BA is explained by an ADP-induced conformational change of the ADP translocator.
Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl.
- BiologyPest management science
- 2009
Cross-resistance to acequinocyl in two bifenazate-resistant strains was shown to be maternally inherited and caused by the combination of two specific mutations in the cytochrome b Q(o) pocket.