Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line.

@article{Tarumoto2004AscorbicAR,
  title={Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line.},
  author={T. Tarumoto and T. Nagai and K. Ohmine and T. Miyoshi and Makiko Nakamura and T. Kondo and K. Mitsugi and Syuji Nakano and K. Muroi and N. Komatsu and K. Ozawa},
  journal={Experimental hematology},
  year={2004},
  volume={32 4},
  pages={
          375-81
        }
}
OBJECTIVE Imatinib, a BCR/ABL tyrosine kinase inhibitor, has shown remarkable clinical effects in chronic myelogenous leukemia. However, the leukemia cells become resistant to this drug in most blast crisis cases. The transcription factor Nrf2 regulates the gene expression of a number of detoxifying enzymes such as gamma-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme in glutathione (GSH) synthesis, via the antioxidant response element (ARE). In this study, we examined the… Expand
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