Ascorbic acid reduces the genetic damage caused by miltefosine (hexadecylphosphocholine) in animals infected by Leishmania (Leishamnia) infantum without decreasing its antileishmanial activity

@article{CasteloBranco2019AscorbicAR,
  title={Ascorbic acid reduces the genetic damage caused by miltefosine (hexadecylphosphocholine) in animals infected by Leishmania (Leishamnia) infantum without decreasing its antileishmanial activity},
  author={P. V. Castelo-Branco and H. J. Alves and Raissa Lacerda Pontes and Vera Lucia Maciel-Silva and Silma Regina Ferreira Pereira},
  journal={International Journal for Parasitology: Drugs and Drug Resistance},
  year={2019},
  volume={9},
  pages={8 - 15}
}
Leishamaniasis is a neglected disease caused by over 20 Leishmania species, occurring in more than a hundred countries. Miltefosine (hexadecylphosphocholine) is the single oral drug used in treatment for leshmaniases, including cases of infections resistant to pentavalent antimony. Our group has recently demonstrated the ability of miltefosine to cause genomic lesions by DNA oxidation. Acknowledging that antioxidant compounds can potentially modulate Reactive Oxygen Species (ROS), our study… Expand
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