Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear.

@article{Heinrich2008AscorbicAR,
  title={Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear.},
  author={U Heinrich and Ilka Fischer and Juergen Brieger and Andreas Ruemelin and Irene Schmidtmann and Huige Li and Wolf J{\"u}rgen Mann and Kai Helling},
  journal={The Laryngoscope},
  year={2008},
  volume={118 5},
  pages={837-42}
}
OBJECTIVES Noise-induced hearing loss can be caused, among other causes, by increased nitric oxide (NO) production in the inner ear leading to nitroactive stress and cell destruction. Some studies in the literature suggest that the degree of hearing loss (HL) could be reduced in an animal model through ascorbic acid supplementation. To identify the effect of ascorbic acid on tissue-dependent NO content in the inner ear of the guinea pig, we determined the local NO production in the organ of… CONTINUE READING

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