Ascorbic acid protects against colistin sulfate-induced neurotoxicity in PC12 cells.

@article{Liu2013AscorbicAP,
  title={Ascorbic acid protects against colistin sulfate-induced neurotoxicity in PC12 cells.},
  author={Yang Liu and Chongshan Dai and Ruixia Gao and Jichang Li},
  journal={Toxicology mechanisms and methods},
  year={2013},
  volume={23 8},
  pages={584-90}
}
This study aimed to examine the protective effect of ascorbic acid against colistin-induced neurotoxicity mediated by oxidative stress, a potential mechanism. An in vitro neurotoxicity model was established with PC12 cells exposed to 125 µg/mL colistin sulfate for 24 h. PC12 cells were treated with colistin (125 µg/mL) in the absence and presence of ascorbic acid (0.1, 1.0 and 10 µM/mL) for 24 h. Both 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay and lactate… CONTINUE READING
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