Ascorbic acid promotes recovery of cellular functions following toxicant-induced injury.

@article{Nowak2000AscorbicAP,
  title={Ascorbic acid promotes recovery of cellular functions following toxicant-induced injury.},
  author={Graz Yna Nowak and Christopher A. Carter and Rick G Schnellmann},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={167 1},
  pages={37-45}
}
We have shown that renal proximal tubular cells (RPTC) recover cellular functions following sublethal injury induced by the oxidant t-butylhydroperoxide but not by the nephrotoxic cysteine conjugate dichlorovinyl-L-cysteine (DCVC). This study investigated whether L-ascorbic acid phosphate (AscP) promotes recovery of RPTC functions following DCVC-induced injury. DCVC exposure (200 microM; 100 min) resulted in 60% RPTC death and loss from the monolayer at 24 h independent of physiological (50… CONTINUE READING
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