Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using 31P and hyperpolarized 13C nuclear magnetic resonance.

@article{Shaghaghi2015AscorbicAP,
  title={Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using 31P and hyperpolarized 13C nuclear magnetic resonance.},
  author={Hoora Shaghaghi and Stephen J. Kadlecek and Sarmad Siddiqui and Mehrdad Pourfathi and Hooman Hamedani and Justin T Clapp and Harrilla Profka and Rahim R. Rizi},
  journal={Free radical biology & medicine},
  year={2015},
  volume={89},
  pages={62-71}
}
Ex vivo lung perfusion (EVLP) has recently shown promise as a means of more accurately gauging the health of lung grafts and improving graft performance post-transplant. However, reperfusion of ischemic lung promotes the depletion of high-energy compounds and a progressive loss of normal mitochondrial function, and it remains unclear how and to what extent the EVLP approach contributes to this metabolic decline. Although ascorbate has been used to mitigate the effects of ischemia-reperfusion… CONTINUE READING
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