Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscle.

@article{Jain1992AscorbicAP,
  title={Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscle.},
  author={A K Jain and J M{\aa}rtensson and Tejas Mehta and Alfred N Krauss and Peter A. M Auld and Alton Meister},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 11},
  pages={5093-7}
}
Glutathione deficiency in adult mice leads to lung type 2 cell lamellar body and mitochondrial damage; as reported here, these effects are associated with marked decrease of the levels of phosphatidylcholine (the main component of lung surfactant) in the lung and the bronchoalveolar lining fluid. Severe mitochondrial damage was also found in skeletal muscle. Treatment with ascorbate (1-2 mmol per kg of body weight per day), which led to greatly increased (approximately 2-fold) levels of lung… CONTINUE READING
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