Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.

@article{Shankaran2001AscorbicAP,
  title={Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.},
  author={Mahalakshmi Shankaran and Bryan K. Yamamoto and Gary A. Gudelsky},
  journal={Synapse},
  year={2001},
  volume={40 1},
  pages={
          55-64
        }
}
  • Mahalakshmi Shankaran, Bryan K. Yamamoto, Gary A. Gudelsky
  • Published in Synapse 2001
  • Psychology, Medicine
  • MDMA-induced 5-HT neurotoxicity has been proposed to involve oxidative stress due to increased formation of hydroxyl radicals. Recently, MDMA-induced 5-HT neurotoxicity has been shown to be accompanied by a suppression of behavioral and neurochemical responses to a subsequent injection of MDMA. The intent of the present study was to examine whether suppression of the MDMA-induced formation of hydroxyl radicals by an antioxidant, ascorbic acid, attenuates both the MDMA-induced depletion of 5-HT… CONTINUE READING

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