Ascorbic acid prevents 3,4‐methylenedioxymethamphetamine (MDMA)‐induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5‐HT

@article{Shankaran2001AscorbicAP,
  title={Ascorbic acid prevents 3,4‐methylenedioxymethamphetamine (MDMA)‐induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5‐HT},
  author={M. Shankaran and B. Yamamoto and G. Gudelsky},
  journal={Synapse},
  year={2001},
  volume={40}
}
MDMA‐induced 5‐HT neurotoxicity has been proposed to involve oxidative stress due to increased formation of hydroxyl radicals. Recently, MDMA‐induced 5‐HT neurotoxicity has been shown to be accompanied by a suppression of behavioral and neurochemical responses to a subsequent injection of MDMA. The intent of the present study was to examine whether suppression of the MDMA‐induced formation of hydroxyl radicals by an antioxidant, ascorbic acid, attenuates both the MDMA‐induced depletion of 5‐HT… Expand
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