Ascorbic acid induces a marked conformational change in long duplex DNA.

@article{Yoshikawa2003AscorbicAI,
  title={Ascorbic acid induces a marked conformational change in long duplex DNA.},
  author={Yuko Yoshikawa and Mari Suzuki and Ning Chen and Anatoly A Zinchenko and Shizuaki Murata and Toshio Kanbe and Tonau Nakai and Hidehiro Oana and Kenichi Yoshikawa},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 14},
  pages={3101-6}
}
Ascorbic acid is often regarded as an antioxidant in vivo, where it protects against cancer by scavenging DNA-damaging reactive oxygen species. However, the detailed mechanism of the action of ascorbic acid on genetic DNA is still unclear. We examined the effect of ascorbic acid on the higher-order structure of DNA through real-time observation by… CONTINUE READING