Ascorbic-acid-induced haemolysis in G-6-PD deficiency

  title={Ascorbic-acid-induced haemolysis in G-6-PD deficiency},
  author={Jayesh Mehta and Seema Singhal and B. C. Mehta},
  journal={The Lancet},
High-Dose Vitamin C for Cancer Therapy
The anti-cancer functions of Vit-C are discussed, but also the potential for the use of vit-C as an epigenetic regulator and immunotherapy enhancer and the current state of systems for scavenging reactive oxygen species (ROS), especially in the context of their influencing high-dose Vit- C toxicity for the inhibition of cancer growth.
Vitamin C-induced Hemolysis: Meta-summary and Review of Literature
  • D. JunejaRavi JainP. Nasa
  • Medicine
    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
  • 2022
Vitamin C is generally a safe drug but it should be prescribed with caution and only when benefits outweigh the risks, especially when using high doses and in G6PD deficiency.
Gastrointestinal Endoscopy - Lower
Novel frontiers of agents for bowel cleansing for colonoscopy
The current strategy to increase bowel cleansing before colonoscopy was summarized, and newly bowel cleansing agents were developed with the same efficacy of previous agent but requiring less amount of liquid to improve patients’ acceptability.
Any Role of High-Dose Vitamin C for Septic Shock in 2021?
The majority of evidence so far does not support the routine supplementation of vitamin C in patients with sepsis or septic shock, and there are some ongoing studies of high-dose vitamin C administration in Patients with sePSis and coronavirus disease 2019.
Vitamin C for Sepsis and Septic Shock
Future studies with consistent end points, initiation time with an emphasis on early initiation, and standard vitamin C dosing regimen are needed to determine the overall benefit of vitamin C in sepsis.
High-Dose Vitamin C in Advanced-Stage Cancer Patients
In palliative care, high-dose IVC might be considered as a therapy improving the quality of life and reducing cancer-related symptoms, such as fatigue and bone pain, however, because of the absence of placebo-controlled randomized trials on IVC efficacy in advanced-stage cancer patients, the placebo effect cannot be excluded.
Harm or Benefit of High-Dose Vitamin C in Adult Patients With Sepsis and Glucose-6-Phosphate Dehydrogenase Deficiency?
Future studies of vitamin C in sepsis should include patients with G6PD deficiency as there is insufficient evidence that significant hemolysis occurs at those doses, and where, it is hypothesized, such therapy may be of benefit.