Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase

@article{Lee2011AscorbicAI,
  title={Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase},
  author={Seung-Ah Lee and Young-Ok Son and Sung-Ho Kook and Ki-choon Choi and Jeong-Chae Lee},
  journal={Archives of Dermatological Research},
  year={2011},
  volume={303},
  pages={669-678}
}
Ascorbic acid, a potential antioxidant, is known to inhibit melanogenesis. However, there are conflicting findings that ascorbic acid has very low stability and acts as a pro-oxidant, eventually increasing proliferation and melanin content in melanoma cells. In the present study, we explored the effects of ascorbic acid on the activity and expression of tyrosinase and melanin pigmentation in the presence and absence of α-melanocyte-stimulating hormone (α-MSH) using B16F10 melanoma cells. The… Expand
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