Ascorbic acid enhances radiation-induced apoptosis in an HL60 human leukemia cell line.

@article{Shinozaki2011AscorbicAE,
  title={Ascorbic acid enhances radiation-induced apoptosis in an HL60 human leukemia cell line.},
  author={Koji Shinozaki and Yoichiro Hosokawa and Masakatsu Hazawa and Ikuo Kashiwakura and Kazuhiko Okumura and Tohru Kaku and Eiji Nakayama},
  journal={Journal of radiation research},
  year={2011},
  volume={52 2},
  pages={229-37}
}
This study was conducted to examine the utility of the combined use of ascorbic acid (AsA) and radiation in clinical applications. We investigated cell survival, DNA fragmentation, and caspase activation after X-ray irradiation and AsA treatment of human leukemia HL60 cells. The number of living cells decreased after combined X-ray irradiation and AsA treatment (2 Gy + 5 mM) in comparison with that after X-ray irradiation (2 Gy) or AsA treatment (5 mM) alone. DNA fragmentation was more in the… CONTINUE READING