Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes.

@article{Takahashi2003AscorbicAE,
  title={Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes.},
  author={Tomosaburo Takahashi and Bernadette Lord and Paul Christian Schulze and Ryan M. Fryer and Satinder S Sarang and Steven R. Gullans and Richard T Lee},
  journal={Circulation},
  year={2003},
  volume={107 14},
  pages={1912-6}
}
BACKGROUND Embryonic stem (ES) cells are capable of self-renewal and differentiation into cellular derivatives of all 3 germ layers. In appropriate culture conditions, ES cells can differentiate into specialized cells, including cardiac myocytes, but the efficiency is typically low and the process is incompletely understood. METHODS AND RESULTS We evaluated a chemical library for its potential to induce cardiac differentiation of ES cells in the absence of embryoid body formation. Using ES… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 171 extracted citations

Ascorbic acid induces cardiac differentiation of white adipose tissue-derived stem cells

Molecular and Cellular Biochemistry • 2018
View 5 Excerpts
Highly Influenced

EphB4 Forward‐Signaling Regulates Cardiac Progenitor Development in Mouse ES Cells

Journal of cellular biochemistry • 2015
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…