Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes.

  title={Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes.},
  author={Tomosaburo Takahashi and Bernadette Lord and Paul Christian Schulze and Ryan M. Fryer and Satinder S Sarang and Steven R. Gullans and Richard T Lee},
  volume={107 14},
BACKGROUND Embryonic stem (ES) cells are capable of self-renewal and differentiation into cellular derivatives of all 3 germ layers. In appropriate culture conditions, ES cells can differentiate into specialized cells, including cardiac myocytes, but the efficiency is typically low and the process is incompletely understood. METHODS AND RESULTS We evaluated a chemical library for its potential to induce cardiac differentiation of ES cells in the absence of embryoid body formation. Using ES… CONTINUE READING
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