Ascorbic acid efflux from human brain microvascular pericytes: role of re-uptake.

@article{May2015AscorbicAE,
  title={Ascorbic acid efflux from human brain microvascular pericytes: role of re-uptake.},
  author={J. M. May and Z. Qu},
  journal={BioFactors},
  year={2015},
  volume={41 5},
  pages={
          330-8
        }
}
Microvascular pericytes take up ascorbic acid on the ascorbate transporter SVCT2. Intracellular ascorbate then protects the cells against apoptosis induced by culture at diabetic glucose concentrations. To investigate whether pericytes might also provide ascorbate to the underlying endothelial cells, we studied ascorbate efflux from human pericytes. When loaded with ascorbate to intracellular concentrations of 0.8-1.0 mM, almost two-thirds of intracellular ascorbate effluxed from the cells over… Expand
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