Ascorbic acid-deficient condition alters central effects of methamphetamine

@article{Matsuda1987AscorbicAC,
  title={Ascorbic acid-deficient condition alters central effects of methamphetamine},
  author={Lisa A. Matsuda and Christopher J. Schmidt and James W. Gibb and Glen R. Hanson},
  journal={Brain Research},
  year={1987},
  volume={400},
  pages={176-180}
}
Effects of multiple doses of methamphetamine (METH) were examined in normal and ascorbic acid-deficient (scorbutic) guinea pigs. METH-induced decreases of striatal serotonin concentrations were completely antagonized in scorbutic animals. Elevations of nigral substance P-like immunoreactivity also differed significantly in METH-treated scorbutic compared to METH-treated normal animals. Various lines of evidence indicate that dopamine is an essential mediator of METH-induced effects in both… Expand
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