Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats.

@article{Ikeda1998AscorbicAD,
  title={Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats.},
  author={Saiko Ikeda and Fumihiko Horio and Atsushi Kakinuma},
  journal={The Journal of nutrition},
  year={1998},
  volume={128 5},
  pages={832-8}
}
The ODS rat (genotype od/od), which has a hereditary defect in ascorbic acid biosynthesis, was used to investigate the effects of ascorbic acid deficiency on the hepatic gene expression of both the positive acute phase proteins, haptoglobin and alpha1-acid glycoprotein, and the negative acute phase proteins, apolipoprotein A-I and albumin. Male ODS rats (6 wk old, body weight approximately 140 g) were fed a basal diet containing ascorbic acid (300 mg/kg diet) or a diet without ascorbic acid for… CONTINUE READING