Ascorbic acid antagonizes ethanol-induced locomotor activity in the open-field.

  title={Ascorbic acid antagonizes ethanol-induced locomotor activity in the open-field.},
  author={Marta Miquel and M A Aguilar and Carlos M. G. Aragon},
  journal={Pharmacology, biochemistry, and behavior},
  volume={62 2},
It has been reported that ascorbic acid (AA) antagonizes the physiological and behavioral effects of dopamine (DA). AA reduces locomotor activity induced by dopaminergic agonist drugs. Also, AA amplifies the action of antidopaminergic drugs. Ethanol, like other drugs, produces a release of DA in the mesolimbic pathway, and at some doses, induces locomotor activity in mice. The ethanol-induced locomotor activity could be dopamine-dependent because it can be reduced by antidopaminergic drugs. In… CONTINUE READING

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