Ascorbic acid: chemistry, biology and the treatment of cancer.

  title={Ascorbic acid: chemistry, biology and the treatment of cancer.},
  author={Juan Du and Joseph J. Cullen and Garry R Buettner},
  journal={Biochimica et biophysica acta},
  volume={1826 2},
Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties due to its role in the synthesis of collagen in connective tissues. Ascorbate acts as an electron-donor keeping iron in the ferrous state thereby maintaining the full activity of collagen hydroxylases; parallel reactions with a variety of dioxygenases affect the expression of a wide array of genes, for example… CONTINUE READING
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