Ascorbic acid, glutathione and synthetic antioxidants prevent the oxidation of vitamin E in platelets

@article{Vatassery2006AscorbicAG,
  title={Ascorbic acid, glutathione and synthetic antioxidants prevent the oxidation of vitamin E in platelets},
  author={Govind T. Vatassery and W. E. Smith and Hung T. Quach},
  journal={Lipids},
  year={2006},
  volume={24},
  pages={1043-1047}
}
An earlier report from this laboratory showed that tocopherol in human platelets is oxidized when the platelets are incubatedin vitro in Tyrode medium with arachidonate (or other oxidants). Arachidonate is a more potent oxidizing agent in 50 mM potassium phosphate buffer at pH 7.4 with 0.1 mM ethylenediaminetetraacetic acid (EDTA) than in Tyrode medium. Forty to fifty percent of total platelet tocopherol was oxidized upon incubation with 40–50 μM arachidonate in the phosphate-buffered medium… 
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