Ascorbic Acid Enhances the Effects of 6-Hydroxydopamine and H2O2 on Iron- dependent DNA Strand Breaks and Related Processes in the Neuroblastoma Cell


Neuroblastoma cells accumulate ascorbic acid and iron. It was hypoth esized that these features could be exploited for sensitizing neuroblastoma cells for therapy in combination with reactive oxygen intermediates. In the present study the effects of 6-hydroxydopamine (6-OIIDA) and IM), on metabolic parameters critical for cell survival were investigated in… (More)


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