Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans.

@article{Beckman2001AscorbateRE,
  title={Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans.},
  author={Joshua A Beckman and Allison B. Goldfine and Mary Gordon and Mark A. Creager},
  journal={Circulation},
  year={2001},
  volume={103 12},
  pages={1618-23}
}
BACKGROUND Endothelium-dependent vasodilation is impaired in patients with insulin-dependent and non-insulin-dependent diabetes mellitus and restored by vitamin C administration, implicating a causative role for oxidant stress. Hyperglycemia per se attenuates endothelium-dependent vasodilation in healthy subjects. Accordingly, this study investigated whether impaired endothelium-dependent vasodilation caused by hyperglycemia in nondiabetic humans is restored by administration of the antioxidant… CONTINUE READING