Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.

@article{Armour2001AscorbatePM,
  title={Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.},
  author={J. D. Armour and Karel Tyml and Darcy Lidington and J. X. Wilson},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 3},
  pages={
          795-803
        }
}
Septic patients have low plasma ascorbate concentrations and compromised microvascular perfusion. The purpose of the present experiments was to determine whether ascorbate improves capillary function in volume-resuscitated sepsis. Cecal ligation and perforation (CLP) was performed on male Sprague-Dawley rats. The concentration of ascorbate in plasma and urine, mean arterial blood pressure, and density of continuously perfused capillaries in the extensor digitorum longus muscle were measured 24… 
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Delayed ascorbate bolus protects against maldistribution of microvascular blood flow in septic rat skeletal muscle*
TLDR
The finding that intravenous bolus of ascorbate can protect against these deficits even if delayed 6–24 hrs after the septic insult shows, for the first time, that ascorBate can reverse microcirculatory dysfunction after the onset of sepsis.
Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression.
Short-term effect of ascorbate on bacterial content, plasminogen activator inhibitor-1, and myeloperoxidase in septic mice.
Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice.
TLDR
The hypothesis that administration of ascorbate decreases oxidative stress, prevents endothelial iNOS expression, and improves vascular reactivity in septic skeletal muscle is evaluated and it is suggested that early administration of the drug may be a valuable adjunct treatment of sepsis.
Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis.
TLDR
The present study provides a scientific basis for injection of ascorbate as an adjunct treatment for vascular leakage in sepsis by sequentially inhibiting excessive production of NO and superoxide, formation of peroxynitrite, PP2A activation, and occludin dephosphorylation.
Effect of Ascorbate on Coagulation and Fibrinolytic Factors in the Septic Microvasculature
TLDR
It is observed that sepsis-induced increases in bacterial count, PAI-1 expression and myeloperoxidase content in various organs were not affected by ascorbate, suggesting that the lack of effect of asCorbate on PAi-1 in the tissue may maintain PAI’1’s beneficial role insepsis.
The effects of antioxidants on microvascular oxygenation and blood flow in skeletal muscle of young rats
TLDR
It is demonstrated that antioxidant supplementation significantly impacts the control of spinotrapezius muscle force production in young rats at rest and during contractions.
Effects of antioxidants on contracting spinotrapezius muscle microvascular oxygenation and blood flow in aged rats.
TLDR
Testing the hypothesis that antioxidants would elevate Qm and, therefore, Pmv(O(2)) in aged rats found it likely that this effect arose from antioxidants reducing myocyte redox below the level optimal for contractile performance and directly (decreased tension) or indirectly (altered balance of vasoactive mediators) influencing O(2) delivery and Vm(O (2).
Vitamin C in sepsis.
TLDR
In animal models of polymicrobial sepsis, intravenous ascorbate injection restores microvascular function and increases survival, and it may be possible to improve microv vascular function in sepsi by using intravenous vitamin C as an adjunct therapy.
Vitamin C and Microvascular Dysfunction in Systemic Inflammation
  • K. Tyml
  • Biology, Medicine
    Antioxidants
  • 2017
TLDR
It is proposed that protected/restored arteriolar conduction and capillary bed perfusion by ascorbate contributes to reduced organ injury and improved survival in sepsis.
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References

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