Ascorbate-mediated transmembrane electron transport and ascorbate uptake in leukemic cell lines are two different processes.

@article{Schweinzer1992AscorbatemediatedTE,
  title={Ascorbate-mediated transmembrane electron transport and ascorbate uptake in leukemic cell lines are two different processes.},
  author={E. Schweinzer and Hans Goldenberg},
  journal={European journal of biochemistry},
  year={1992},
  volume={206 3},
  pages={807-12}
}
Transmembrane reduction of extracellular oxidants by K562 and U937 leukemic cells was stimulated by catalytic amounts of ascorbate or dehydroascorbate. This stimulation was not due to transport of ascorbate in different redox states in and out of the cells. The membrane redox cycle was strictly dependent on the presence of the cells at every stage, and showed high affinity for ascorbate with simple linear kinetics. Metabolic inhibitors and sulfhydryl reagents inhibited this stimulation… CONTINUE READING

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