Ascorbate is an outstanding antioxidant in human blood plasma.

  title={Ascorbate is an outstanding antioxidant in human blood plasma.},
  author={Balz Frei and Laura England and Bruce N. Ames},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 16},
We have shown recently that the temporal order of antioxidant consumption in human blood plasma exposed to a constant flux of aqueous peroxyl radicals is ascorbate = protein thiols greater than bilirubin greater than urate greater than alpha-tocopherol and that detectable lipid peroxidation starts only after ascorbate has been consumed completely. In this paper, we show that it is indeed ascorbate that completely protects plasma lipids against detectable peroxidative damage induced by aqueous… CONTINUE READING
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