Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

@article{Chen2007AscorbateIP,
  title={Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.},
  author={Qi Chen and Michael Graham Espey and Andrew Y. Sun and Je-Hyuk Lee and Murali Cherukuri Krishna and Emily B. Shacter and Peter L. Choyke and Chaya Pooput and Kenneth Lee Kirk and Garry R Buettner and Mark Levine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 21},
  pages={8749-54}
}
Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in humans by i.v. administration, selectively kills some cancer cells but not normal cells. We proposed that pharmacologic ascorbate is a prodrug for preferential steady-state formation of ascorbate radical (Asc(*-)) and H(2)O(2) in the extracellular space compared with blood. Here we test this hypothesis in vivo. Rats were administered parenteral (i.v. or i.p.) or oral ascorbate in typical human pharmacologic… CONTINUE READING
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Antioxid Redox Signal 8:243–270

  • JR Stone, S Yang
  • 2006

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