Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.

@article{Lebel2010AscorbateIM,
  title={Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.},
  author={Michel Lebel and Laurent Massip and Chantal Garand and Eric Thorin},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1197},
  pages={40-4}
}
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS. Importantly, mutant Wrn(Deltahel/Deltahel) mice show abnormal increases in visceral fat deposition and fasting blood triglyceride levels followed by insulin resistance and high blood glucose levels. These mice also exhibit increased heart and liver tissue reactive oxygen species concomitantly with… CONTINUE READING
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