Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms.

@article{Davidson1997AscorbateDR,
  title={Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms.},
  author={Jeffrey M. Davidson and P A Luvalle and Ornella Zoia and Daniela Quaglino and Maria Gabriella Giro},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 1},
  pages={
          345-52
        }
}
Ascorbate contributes to several metabolic processes including efficient hydroxylation of hydroxyproline in elastin, collagen, and proteins with collagenous domains, yet hydroxyproline in elastin has no known function. Prolyl hydroxylation is essential for efficient collagen production; in contrast, ascorbate has been shown to decrease elastin accumulation in vitro and to alter morphology of elastic tissues in vivo. Ascorbate doses that maximally stimulated collagen production (10-200 microM… CONTINUE READING

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