Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?

@article{Carr2015AscorbatedependentVS,
  title={Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?},
  author={Anitra C Carr and Geoffrey M. Shaw and Alpha A Berry Fowler and Ramesh Natarajan},
  journal={Critical care},
  year={2015},
  volume={19},
  pages={418}
}
Severe systemic inflammatory response to infection results in severe sepsis and septic shock, which are the leading causes of death in critically ill patients. Septic shock is characterised by refractory hypotension and is typically managed by fluid resuscitation and administration of catecholamine vasopressors such as norepinephrine. Vasopressin can also be administered to raise mean arterial pressure or decrease the norepinephrine dose. Endogenous norepinephrine and vasopressin are… CONTINUE READING

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