Ascorbate as a source of reducing equivalents for the synthesis of aldosterone.

@article{Yanagibashi1990AscorbateAA,
  title={Ascorbate as a source of reducing equivalents for the synthesis of aldosterone.},
  author={K Yanagibashi and Yuji Kobayashi and P. F. Hall},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={170 3},
  pages={1256-62}
}
The three steps in the synthesis of aldosterone (11 beta/18-hydroxylations and aldehyde synthetase) were examined in mitochondria from bovine glomerulosa and fasciculata to study the regulation of aldehyde synthetase. Ascorbate plus NADH shows synergism with malate in stimulating aldehyde synthetase without affecting 11 beta/-18-hydroxylations. The… CONTINUE READING