Ascorbate- and dehydroascorbic acid-mediated reduction of free radicals in the human erythrocyte.

@article{Mehlhorn1991AscorbateAD,
  title={Ascorbate- and dehydroascorbic acid-mediated reduction of free radicals in the human erythrocyte.},
  author={Rolf J. Mehlhorn},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 5},
  pages={2724-31}
}
Nitroxides were used as models of persistent free radicals to study the antioxidant function of ascorbic acid in the human erythrocyte. It was concluded that: 1) ascorbate and other reductant(s) derived from dehydroascorbic acid (DHA) in the presence of thiols are the only significant reducing agents for nitroxides, 2) glutathione and DHA reduce nitroxides by a process that cannot be inhibited by ascorbic acid oxidase, 3) erythrocytes can be depleted of ascorbic acid by exhaustive washing in… CONTINUE READING

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