Ascorbate administration to normal and cholesterol-fed rats inhibits in vitro TBARS formation in serum and liver homogenates.

@article{Santillo1996AscorbateAT,
  title={Ascorbate administration to normal and cholesterol-fed rats inhibits in vitro TBARS formation in serum and liver homogenates.},
  author={Maria Rosaria Santillo and Paolo Mondola and Antonino Milone and A Gioielli and Maurizio Bifulco},
  journal={Life sciences},
  year={1996},
  volume={58 14},
  pages={1101-8}
}
We have recently shown that ascorbate has a hypocholesterolemic and hypotriglyceridemic effect on rats fed a diet enriched with 1.5% cholesterol and 25% hydrogenated coconut oil (Nath diet). In this study we evaluated the effect of intraperitoneal ascorbate administration on susceptibility to lipoperoxidation either in rats fed standard or Nath diet. In normal rats ascorbate treatment decreased (p<0.05) the susceptibility to lipoperoxidation induced by incubation of serum for 24 hours with 2.2… CONTINUE READING