Ascorbate Peroxidase from Leishmania major Controls the Virulence of Infective Stage of Promastigotes by Regulating Oxidative Stress

@inproceedings{Pal2010AscorbatePF,
  title={Ascorbate Peroxidase from Leishmania major Controls the Virulence of Infective Stage of Promastigotes by Regulating Oxidative Stress},
  author={Swati Pal and Subhankar Dolai and Rajesh K. Yadav and Subrata Adak},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Peroxidase represents a heterogeneous group of distinct enzyme family that plays extremely diverse biological functions. Ascorbate peroxidase from Leishmania major (LmAPX) has been shown to be central to the redox defense system of Leishmania. To investigate further its exact physiological role in Leishmania, we attempted to create LmAPX -knockout mutants by gene replacement in L. major strains. METHODOLOGY/PRINCIPAL FINDINGS The null mutant cell culture contains a higher… CONTINUE READING

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