Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

@article{Schuijers2015Ascl2AA,
  title={Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.},
  author={Jurian Schuijers and Jan Philipp Junker and Michal Mokry and Pantelis Hatzis and Bon-Kyoung Koo and Valentina Sasselli and Laurens G. van der Flier and Edwin Cuppen and Alexander van Oudenaarden and Hans Clevers},
  journal={Cell stem cell},
  year={2015},
  volume={16 2},
  pages={158-70}
}
The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and in many other adult organs. The transcription factor Ascl2 (a Wnt target gene) is a master regulator of intestinal stem cell identity. It is unclear how the continuous Wnt gradient along the crypt axis is translated into discrete expression of Ascl2 and discrete specification of stem cells at crypt bottoms. We show that (1) Ascl2 is regulated in a direct autoactivatory loop, leading to a distinct on/off… CONTINUE READING
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A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

  • J. H. van Es, A. Haegebarth, +8 authors H. Clevers
  • Mol. Cell. Biol
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