Ascl1 is required for oligodendrocyte development in the spinal cord.

@article{Sugimori2008Ascl1IR,
  title={Ascl1 is required for oligodendrocyte development in the spinal cord.},
  author={Michiya Sugimori and Motoshi Nagao and Carlos M. Parras and Hiroko Nakatani and M{\'e}lanie Lebel and François Guillemot and Masato Nakafuku},
  journal={Development},
  year={2008},
  volume={135 7},
  pages={1271-81}
}
Development of oligodendrocytes, myelin-forming glia in the central nervous system (CNS), proceeds on a protracted schedule. Specification of oligodendrocyte progenitors (OLPs) begins early in development, whereas their terminal differentiation occurs at late embryonic and postnatal periods. How these distinct steps are controlled remains unclear. Our previous study demonstrated an important role of the helix-loop-helix (HLH) transcription factor Ascl1 in early generation of OLPs in the… CONTINUE READING
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