Ascl1 genetics reveals insights into cerebellum local circuit assembly.

  title={Ascl1 genetics reveals insights into cerebellum local circuit assembly.},
  author={Anamaria Sudarov and Rowena K Turnbull and Euiseok J. Kim and M{\'e}lanie Lebel-Potter and François Guillemot and Alexandra L. Joyner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 30},
Two recently generated targeted mouse alleles of the neurogenic gene Ascl1 were used to characterize cerebellum circuit formation. First, genetic inducible fate mapping (GIFM) with an Ascl1(CreER) allele was found to specifically mark all glial and neuron cell types that arise from the ventricular zone (vz). Moreover, each cell type has a unique temporal profile of marking with Ascl1(CreER) GIFM. Of great utility, Purkinje cells (Pcs), an early cohort of Bergmann glia, and four classes of… CONTINUE READING

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